171 MACROPHAGE INFILTRATION AND MATRIX DISRUPTION IN∼RDS

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Effects of diabetes and hypertension on macrophage infiltration and matrix expansion in the rat kidney

BACKGROUND In experimental models of diabetes mellitus, aggravation of renal injury by concomitant hypertension has been described. Inflammatory mechanisms contribute to renal damage in both diseases. We investigated whether hypertension and diabetes mellitus act synergistically to induce macrophage infiltration and matrix expansion in the kidney. METHODS Insulin-dependent diabetes mellitus w...

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Mammary epithelial polarity and macrophage infiltration

Loss of epithelial cell polarity and inflammation are hallmarks of breast cancer development. Although the association between the disruption of tissue polarity and inflammation has been demonstrated, we know little about how these two events are coupled. Using the 3D co-culture model of mammary epithelial cells and monocytes, a recent study reveals a link between disruption of epithelial polar...

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Prognostic significance of macrophage infiltration in leiomyosarcomas.

PURPOSE Macrophages are migratory cells that are frequently recruited to the site of tumors. Their presence is associated with poor clinical outcome in a variety of epithelial malignancies. The aim of this study is to examine the prognostic significance of tumor-associated macrophages in sarcomas. EXPERIMENTAL DESIGN Global gene expression profiling data of a series of soft tissue tumors were...

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Macrophage Infiltration in Acute Coronary Syndromes

Background Rupture of atherosclerotic plaques is probably the most important mechanism underlying the sudden onset of acute coronary syndromes. Macrophages may release lytic enzymes that degrade the fibrous cap and therefore produce rupture of the atherosclerotic plaque. This study was designed to quantify macrophage content in coronary plaque tissue from patients with stable and unstable coron...

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Macrophage infiltration and genetic landscape of undifferentiated uterine sarcomas.

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ژورنال

عنوان ژورنال: Pediatric Research

سال: 1994

ISSN: 0031-3998,1530-0447

DOI: 10.1203/00006450-199407000-00171